Interestingly, there is a similar case showing a synergistic effect from the alleles of GSTM1-null, GSTT1-present, GSTA1/T (low activity), and GSTP1/G (low activity) on promoting risk for clear cell renal cell carcinoma (Coric et al., 2016). Here, GSTM1 is linked to clear cell renal carcinoma.