In addition, although some studies have reported an association of blood amyloidβ and phosphorylated tau (p181, p217, and p231) levels with the rate of cognitive decline (Verberk et al., 2020), it has been shown that the cumulative incidence of dementia in amyloid and tau positive cognitively unimpaired individuals in their seventies is <20% at 5 years and <50% at 14 years, suggesting these deposits are not strong predictors of cognitive decline (Vos et al., 2013). The gene discussed is MAPT; the disease is dementia.