TARDBP and amyotrophic lateral sclerosis: Mis-localisation of mutant TDP-43 A382T in neuronal SH-SY5Y cells and lymphoblastoid cell lines from an ALS patient resulted in the formation of R-loops, DSBs and Fanconi anemia repair centres, involved in the repair of the inter-strand crosslinks and replication fork blockages (Giannini et al., 2020).