DNA damage has also been shown to induce features of TDP-43 pathology – cytoplasmic mis-localisation and stress granule (SG) formation – in NSC-34 cells and mouse primary cortical neurons expressing either wildtype and or ALS-associated mutants A315T and Q331K (Konopka et al., 2020). The gene discussed is TARDBP; the disease is amyotrophic lateral sclerosis.