TARDBP and amyotrophic lateral sclerosis: Nevertheless, the direct involvement of TDP-43 and FUS in DNA repair mechanisms is significant given that TDP-43 is implicated in a pathological form in 97% of ALS cases (Heyburn and Moussa, 2017) and similarly, FUS pathology is now thought to be present in sporadic ALS (90% of all ALS) (Tyzack et al., 2019).