MAPT and early-onset autosomal dominant Alzheimer disease: Accumulation of amyloid-beta (Aβ) peptides and phosphorylated tau (p-tau) in the brain are both key pathological features of the Alzheimer’s disease (Glenner and Wong, 1984; Grundke-Iqbal et al., 1986; Jack et al., 2018; Drummond et al., 2020).