TARDBP and Alzheimer disease: AD is the most common pathology of PCA, whereas Lewy body disease, corticobasal degeneration, and prion disease are pathologically less frequently associated (Holden et al., 2020); however, most cases of SD have TDP-43 pathology at post mortem, and a small minority are accounted for tauopathies and AD (Marshall et al., 2018).