Additionally, we observed more DEGs unique to APOE3/4 cells in AD versus control when compared to DEGs for APOE3/3 cells in AD versus control and more DEG overlaps across cell types in APOE3/4 AD, suggesting distinct disease-relevant molecular profiles between APOE genotypes and more global AD-related molecular responses when one copy of the APOE4 allele is present. Here, APOE is linked to Alzheimer disease.