GPC5 and Alzheimer disease: To highlight some of these DEGs that overlap most across cell types, in the APOE3/3 case-control comparisons, six DEGs –ATP1B1 (Wen et al., 2018), a sodium and potassium ATPase necessary for regulating ionic gradients; CST3 (Hua et al., 2012), an AD risk factor; GPC5 (Shin et al., 2013), a neurotrophic factor; MEG3 (Zhou et al., 2012), a long non-coding RNA and apoptosis regulator; NRXN1; and LINC00486, a relatively uncharacterized long non-coding transcript – were shared by all cell types.