APOE and Alzheimer disease: In addition to identifying shared DEGs across cell types and APOE genotypes, we also observed a larger range of expression change in the analysis of APOE3/4 AD versus control (−0.834, 1.032; median = −0.273) compared to the analysis of APOE3/3 AD versus control (−0.503,1.115; median = 0.342), which we visualized in a few shared DEGs such as LINGO1, NRXN1, RASGEF1B, and CLU (Figure 3B).