APOE and Alzheimer disease: Largely, when comparing AD to non-AD cells in the entorhinal cortex, while we observed changes relevant to AD pathophysiology across APOE3/3 and APOE3/4 genotypes, we also observed flipped DEG expression profiles across both APOE genotypes primarily in non-neuronal cells, and more universal transcriptional changes and changes of higher amplitude in the APOE3/4 AD versus control comparison as compared to APOE3/3 AD versus control comparison.