DHFR and Alzheimer disease: We observed DEGs previously linked to AD [CLU (Kok et al., 2011; Karch and Goate, 2015), CCK (Mazurek and Beal, 1991; Chen et al., 2019; Plagman et al., 2019), NRGN (Thorsell et al., 2010; Jin et al., 2013), DHFR (Cario et al., 2011; Philip et al., 2015), ERBB4 (Mitchell et al., 2013; Mouton-Liger et al., 2020), NRXN1 (Mozhui et al., 2011)], which were shared by APOE3/3 and APOE3/4 cells.