LINC00486 was upregulated in all APOE3/3 cell types in AD, ATP1B1, GPC5, MEG3, and NRXN1 were downregulated in all APOE3/3 cell types in AD, and CST3 was downregulated in all APOE3/3 cell types in AD, except OPCs where it was upregulated. This evidence concerns the gene LINC00486 and Alzheimer disease.