Of these shared DEGs, a few with higher expression changes between AD and controls include MBP, a gene important for myelination (Koenning et al., 2012; Ferrer and Andrés-Benito, 2020) that was upregulated in all APOE3/4 cell types in AD except oligodendrocytes, and LINGO1, which was upregulated in all APOE3/4 cell types as well as APOE3/3 astrocytes and OPCs in AD. Here, MBP is linked to Alzheimer disease.