In APOE3/4 OPCs, we observed upregulated modules for the ferritin, GAIT and LINGO1-TROY-NgR complexes, and downregulation for glutamatergic synaptic activity, plasma membrane and cell organization, and lipoprotein density in AD, which may have implications for neuronal integrity and lipid transport and metabolism. This evidence concerns the gene LINGO1 and Alzheimer disease.