In oligodendrocytes, which provide myelination, APOE3/3 carriers in the prefrontal cortex showed an upregulation of the ITGAV-ITGB-SPP1 complex and downregulation of pathways related to myelin organization (e.g., juxtaparanode region of axon), ion transport activity, protein refolding, and regulation of MAP kinase signaling activity (e.g., positive regulation of Erk1 and Erk2 in AD). Here, SPP1 is linked to Alzheimer disease.