Transcriptomics represent a valuable means of understanding molecular underpinnings in disease conditions (Magistri et al., 2015; Allen et al., 2016; Wang et al., 2016; Patel et al., 2019; Wan et al., 2020; Neff et al., 2021); however, to our knowledge, in AD, APOE isoforms are yet to be investigated at a single-cell level, which can depict molecular profiles that would be otherwise masked in a bulk analysis. The gene discussed is APOE; the disease is Alzheimer disease.