APOE and Alzheimer disease: We performed an APOE genotype-stratified differential gene expression (DGE) analysis comparing age-matched AD cases to controls, with sex as a covariate, in excitatory (Ex) and inhibitory (In) neurons for the prefrontal cortex specifically, undistinguished neurons (Neu) for the entorhinal cortex, and astrocytes (Ast), microglia (Mic), oligodendrocytes (Oli), and OPCs for both cohorts (Supplementary Figures 1, 2).