LINC00486 was upregulated in all APOE3/3 cell types in AD, ATP1B1, GPC5, MEG3, and NRXN1 were downregulated in all APOE3/3 cell types in AD, and CST3 was downregulated in all APOE3/3 cell types in AD, except OPCs where it was upregulated. The gene discussed is ATP1B1; the disease is Alzheimer disease.