Compared to the prefrontal cortex, the entorhinal cortex, which is implicated in early stages of AD where tau begins to accumulate and the occurrence of synaptic and neuronal loss is associated with the onset of cognitive impairment (Khan et al., 2014; Lane et al., 2018; Long and Holtzman, 2019), had a larger expression change range for DEGs overall, implying a greater magnitude of molecular changes in this region in AD. The gene discussed is MAPT; the disease is Cognitive impairment.