SNCA and synucleinopathy: In a group of neurodegenerative disorders (NDDs) known as the α-synucleinopathies, the highly soluble presynaptic protein α-synuclein (Uéda et al., 1993; Spillantini et al., 1998; Clayton and George, 1999; Vilar et al., 2008; Uzuegbunam et al., 2020; Korat et al., 2021) is predominantly present as fibrillary insoluble protein aggregates (α-syn) included in Lewy bodies (LB), Lewy neurites (LN), and glial cytoplasmic inclusions (GCI).