TP53 and Alzheimer disease: p53 regulates a heterogeneous variety of biological functions, which includes neuronal activities including outgrowth and protection of connectivity, and redox homeostasis (Li et al., 2019), these findings reinforce the hypothesis that loss of function of p53 due to its conformational change in the early stages of AD may contribute to several associated pathologies including synapse dysfunction, inflammation, and oxidative stress.