MAPT and Alzheimer disease: Growing evidence proposes oxidative stress to be a critical factor in both AD initiation and progression with a strong relationship to Aβ and Tau-induced neurotoxicity forming feedback loops to accelerate AD progression (Mocchegiani et al., 2004; Puca et al., 2008, 2010a; Lanni et al., 2010a; Zhao and Zhao, 2013).