ApoE2 and apoE3 but not apoE4 upregulate genes expressing heat shock protein and other protein folding chaperones, which protect neurons from aggregation and accumulation of misfolded proteins as this is often a leading pathological event in several neurodegenerative diseases (Galvin et al., 2006; Srivastava et al., 2012; Crippa et al., 2016; Ousman et al., 2017). The gene discussed is APOE; the disease is neurodegenerative disease.