Other studies have shown that the number of ILC2s is increased in patients with severe asthma and persistent eosinophilia compared to patients with mild asthma, with the greatest number of IL-5+IL-13+ILC2s in the airways observed in patients with uncontrolled disease and high eosinophilia despite treatment with high-dose oral corticosteroids [100, 101, 102]. This evidence concerns the gene IL5 and Increased total eosinophil count.