Qi et al.’s (2016a) and Weng et al.’s (2016) study showed that the functional activities of INS were positively correlated with IBS symptoms. Qi et al. (2015) showed that the average DMN FC was negatively correlated with IBS-SSS in IBS patients. Otherwise, Ke et al. (2015) found that the IBS-SSS scores positively correlated with ReHo values in the left thalamus (THA) and negatively correlated with those in the right ventral medial PFC and MFG. Two studies showed that GSRS scores were positively correlated activities of midbrain and PoCG (Li et al., 2018; Chen et al., 2021). The gene discussed is INS; the disease is irritable bowel syndrome.