Indeed, RABL6A protein expression is dramatically increased in MPNSTs compared to patient-matched, benign neurofibromas.19 Notably, RABL6A controls many other cancer pathways besides CDK-RB1, including p53,29,32 AKT,34 and Myc.19,32,35 Therefore, we speculated it might have different effects on MPNST growth depending on the genetic context. This evidence concerns the gene RB1 and malignant peripheral nerve sheath tumor.