MYC and cancer: It is well established that Myc induces multiple levels of DNA damage, chromosomal and genomic instability, and remodeling of the nuclear architecture, ultimately promoting neoplasia.46 Loss of p53, the “guardian of the genome,” 47 likewise induces significant genomic instability in cancer cells, which is enhanced by dysregulated Myc.46 Our findings indicate the absence of p53 is responsible for the atypia and polyploidy seen in NP tumors and suggest the upregulation of Myc following continuous RABL6A loss in those lesions further accentuates that malignant phenotype.