This seems likely given the prominent role of Myc in aggressive cancers.41 It is also possible that the selective retention of YAP in Nf1 + p53 inactivated tumors may contribute to their advanced malignant phenotype, as constitutive YAP activation drives genomic instability and represents a new potential target for MPNST therapy.1,42. Here, MYC is linked to malignant peripheral nerve sheath tumor.