Wu et al. demonstrated (1) elevated YAP expression in human MPNSTs, (2) YAP hyperactivity in Schwann cells induces MPNSTs, and (3) co-targeting YAP and PDGFR pathways suppressed MPNST growth.30 More recently, Velez-Reyes et al. employed CRISPR-Cas9 editing of putative MPNST driver genes and identified Hippo-YAP pathway as a likely central driver of MPNST development.31 Here, PDGFRB is linked to malignant peripheral nerve sheath tumor.