8,9 Others employed Sleeping Beauty transposon-based mutagenesis in p53 mutant mice with overexpressed EGFR to identify cooperating mutations in MPNST pathogenesis.10 Alterations in Wnt/β-catenin, PI3K-AKT-mTOR, and growth factor receptor signaling pathways were found to promote tumorigenesis in concert with p53 loss and EGFR activation. This evidence concerns the gene EGFR and malignant peripheral nerve sheath tumor.