HDAC7 and escherichia coli infection: In conclusion, NA could alleviate the clinical symptoms, the damage of intestinal morphology, and intestinal inflammation in weaned piglets infected ETEC K88, and NA may improve intestinal antimicrobial peptides to enhance resistance of E. coli infection by regulating intestinal microflora and its metabolites, histone deacetylase SIRT1 and HDAC7, histone modification sites (acH3K9, acH3K27, and pH3S10) in the promoter region.