In this study, we provided the first experimentalevidence on thefunctional role of SEMA6D in normal and tumorigenic breast cell lines.However, there is an abundant room for further investigations to answerthe questions such as interacting partners on the cell surface, upstreamregulators, and downstream mediators of SEMA6D to develop a full pictureof SEMA6D’s role in breast cancer. Here, SEMA6D is linked to breast cancer.