We found that patients in the goal-directed fluid treatment group G had lower IL-6 and IL-10 levels, lower lung infection scores (CIPS), and shorter duration of antibiotic use in elderly patients undergoing single-lung ventilation after total endoscopy for esophageal cancer compared with those of control group C. There also seemed to be a tendency for fewer complications and shorter hospital stays in group G. This evidence concerns the gene IL10 and esophageal cancer.