Fabbri et al. [49] found that miRNA-21 and miRNA-29a carried in CSC-Exos can bind to Toll-like receptor 8 (TLR8) on the surface of tumor-associated macrophages (TAMs), triggering the NF-κB pathway and the secretion of interleukin-6 (IL-6). This evidence concerns the gene IL6 and neoplasm.