Interestingly, the multivariate analysis showed that the baseline of lung metastasis, NLR, LMR, and CD3+CD8+ T cell count were independent prognostic factors, which suggest that patients with lung metastasis, high NLR, low LMR, and high CD3+CD8+ T cells in baseline correlate with poor response in treatment of ICI, which suggest that LC patients with no lung metastasis, lower NLR, higher LMR, and higher CD3+CD8+ T cells show a better OS. The gene discussed is CD8A; the disease is laryngotracheoesophageal cleft.