However, the cell cycle arrests in G1 phases were increased miR-146b-3p inhibitor groups of colon cancer cells, while the knockdown of PRSS8 significantly reversed the effect of miR-146b-3p silencing on cell cycle (Figures 4(h) and 4(i), P < 0.05). The gene discussed is PRSS8; the disease is malignant colon neoplasm.