In our validation cohort, high expression of ARMCX1 in GC was markedly related to T classification (OR = 9.048 for T4 vs. T1-T3), TNM stage (OR = 3.600 for stage III vs. stage I&II), and LNM (OR = 3.600 for yes vs. no). Here, ARMCX1 is linked to gastric cancer.