Furthermore, like in AD, the PINK1/Parkin mediated mitophagic pathway is impaired in PD, again leading to an accumulation of dysfunctional mitochondria, limited autophagy, and exacerbated accumulation of proteins in cells that lead to further disruption of key cellular functions (Narendra et al., 2008; Clark et al., 2021). The gene discussed is PRKN; the disease is Alzheimer disease.