Ischemic preconditioning can induce store-operated calcium entry (SOCE) and the release of Ca2+, preventing the downregulation of stromal interacting molecule 1(STIM1) and calcium-release-activated-calcium channel protein 1(ORAI1) induced by ischemia-reperfusion injury and restoring the Ca2+ homeostasis of ER, thereby playing a neuroprotective role [199]. Here, ORAI1 is linked to ischemia reperfusion injury.