Conversely, pretreatment with miR-122-5p antagomir impaired the beneficial effects of adipose-derived exosomes on ARDS in vivo, which is consistent with the enhanced expression of TGF-βR1 and phosphorylation of TGF-βR1 and Smad2 (Figure 2(j)). This evidence concerns the gene TGFBR1 and acute respiratory distress syndrome.