In the present study, the mice manifested the sepsis symptoms such as upside-down hair, loose stools, hunched back, shortness of breath, and white viscous material around the eyes after the intraperitoneal injection of LPS at a dose of 15 mg/kg, and the 7-day survival rate was decreased significantly, while the expression levels of the TNF-α, IL-6, IL-1β, and IL-18 in the serum and hippocampus of mice after LPS injection were increased significantly. Here, IL1B is linked to Sepsis.