An n-6 PUFA–enriched high-fat diet induced hepatic steatosis and fibrosis, along with the activation of the NLRP3 inflammasome, in mice [59], whereas the inhibition of n-6 PUFA metabolites reduced pro-inflammatory factor secretion and inhibited NLRP3 inflammasome activation [60]. The gene discussed is NLRP3; the disease is fatty liver disease.