Probiotic supplement studies reported that administration of Lactobacillus plantarum 299v decreased circulating leptin levels, reduced myocardial infarcts and improved ventricular function and remodeling after left anterior descending artery ligation (57), and another study showed that saccharomyces boulardii was effective in improving left ventricular ejection fraction and left atrial diameter in patients with chronic heart failure (58). The gene discussed is LEP; the disease is congestive heart failure.