Echocardiography showed that compared with the control group, HF mice had diastolic and systolic dysfunctions, the levels of EF, FS, and E/A were decreased (Figures 1A–C), and the expressions of hypertrophy and HF indexes ANP and BNP were significantly increased (Figures 1D,E), indicating that an HF model was successfully established in this study. Here, NPPB is linked to hydrops fetalis.