In RIPK3–/– mice with HF, the expression of cleaved caspase 3 was significantly lower compared with the control group, and the same result was observed in AAV-RIPK3-shRNA-infected mice, indicating that depletion or inhibition of RIPK3 could effectively reduce the occurrence of myocardial necroptosis. The gene discussed is CASP3; the disease is hydrops fetalis.