Previous studies on the role of 5-HT3R antagonism related to anxiety remain contradictory (38, 68), Of note, our results demonstrate the absence of any difference in adult state and trait anxiety levels between TC and NP animals and neonatal 5-HT1aR or 5-HT3R modulation, suggesting receptor modulation does have an additive effect on anxiety. The gene discussed is HTR3A; the disease is Anxiety.