In a murine model of anti-GBM glomerulonephritis, mice treated with rapamycin at the time of immunization were protected from glomerulonephritis and renal IL-6 expression was reduced, whereas rapamycin treatment given 14 days after immunization resulted in a significant increase in both albuminuria and renal IL-6 expression, suggesting that the time when rapamycin treatment is initiated determines whether the drug exerts a beneficial or otherwise effect (Hochegger et al., 2008). Here, IL6 is linked to glomerulonephritis.