Furthermore, Luminex assay found that the serum concentrations of D2D, BNP, CX3CL1, IL-4 and IL-10 were similar in the control and United Kingdom group, and concentrations of D2D, BNP, CX3CL1 in the mice model of APE were significantly increased, but concentrations of IL-4 and IL-10 were significantly decreased, which could be reversed following urokinase treatment (Figure 2F). Here, NPPB is linked to apparent mineralocorticoid excess.