In summary, the available evidence shows that Qili Qiangxin Capsule combined with conventional western medicine can significantly improve the clinical efficacy rate, LVEF, LVEDD, LVESD, BNP, and 6-MWT, decrease the levels of hs-CRP, IL-6, TNF-α, and HMGB1 in DCM patients, and reduce the occurrence of adverse reactions. This evidence concerns the gene HMGB1 and familial dilated cardiomyopathy.