However, no constitutively active Rho GTPase mutations have been found in human cancers (Rihet et al., 2001; Fritz et al., 2002), and clinical and experimental studies show a link between enhanced RhoA expression and poor clinical outcome in breast cancer (Bellizzi et al., 2008; Chan et al., 2010; Ma et al., 2010). This evidence concerns the gene RHOA and breast carcinoma.