In breast cancer, Nrf2 activation enhances Rho expression and downstream proteins such as focal adhesion kinase 1 (FAK), modulator of volume-regulated anion channel current 1 (MLC), and Rho-associated coiled-coil-containing protein kinase 1 (ROCK), whereas it lowers estrogen-related receptor (ERR1) expression. The gene discussed is PTK2; the disease is breast cancer.