Moreover, several researchers have demonstrated abnormally active Nrf2 in several breast cancer cells (Nioi and Nguyen, 2007; Syed Alwi et al., 2012; Zhong et al., 2013), and recent genetic investigations of breast cancers revealed the crucial role of Nrf2 in oncogenesis (Hayes and McMahon, 2009; Denicola et al., 2011). The gene discussed is NFE2L2; the disease is breast cancer.