In addition, we found that the anti-COVID-19 and anti-STAD effects of VD3 may be associated with core genes such as IL1A, CXCL8, ALB, CSF2, and SERPINE1. Next, we speculated that the anti-COVID-19/STAD effects of VD3 might be associated with the core genes IL1A, CXCL8, ALB, CSF2 and SERPINE1, and then did molecular docking to verify the speculation. The gene discussed is SERPINE1; the disease is COVID-19.