For example, METTL3-mediated m6A mRNA methylation promoted the proliferation of hepatoblastoma through the regulation of CTNNB1 (Liu L. et al., 2019), while METTL3 promoted temozolomide resistance by increasing the expression of MGMT and ANPG (Shi et al., 2021). The gene discussed is MPG; the disease is hepatoblastoma.