Since mitochondrial dysfunction is the basis of the pathogenesis of most neurodegenerative diseases, it is not surprising that the mitochondrial deacetylase SIRT3 plays a key role in several brain diseases, such as Parkinson’s disease (PD), Alzheimer’s disease (AD), Huntington’s disease (HD), and stroke (Gomes et al., 2020). This evidence concerns the gene SIRT3 and Alzheimer disease.