SIRT3 and Huntington disease: Since mitochondrial dysfunction is the basis of the pathogenesis of most neurodegenerative diseases, it is not surprising that the mitochondrial deacetylase SIRT3 plays a key role in several brain diseases, such as Parkinson’s disease (PD), Alzheimer’s disease (AD), Huntington’s disease (HD), and stroke (Gomes et al., 2020).