To open up the possibility of using givinostat for other misfolded protein rescue, we investigated the impact of givinostat alone or in combination with the FDA-approved CF treatments Lumacaftor (VX-809) or Orkambi (VX-770 + VX-809) on CFTR (Van Goor et al., 2006, 2009). This evidence concerns the gene CFTR and cystic fibrosis.