The present study used a model of ApoE−/− C57BL/6 mice in which pristane administration resulted in SLE combined with atherosclerosis, presenting reduced spontaneous activity, marked alopecia, splenomegaly, and significantly higher levels of ANA and anti-dsDNA, in agreement with previous reports (Chen et al., 2016b). This evidence concerns the gene APOE and systemic lupus erythematosus.