Fewer patients progressing to severe type: 4 vs. 12; RR 0.28 [0.08, 0.93], p = 0.03;reduction in duration (p < 0.001) and incidence of SIRS (p = 0.008); lower CRP concentration (p = 0.005); lower activated partial thromboplastin time (p = 0.02); higher CD4 + (helper) T cells (p = 0.0004). This evidence concerns the gene CD4 and systemic inflammatory response syndrome.