MAPT and Alzheimer disease: Removing Nrf2 increased the levels of Aβ and phosphorylated tau and enhanced neurodegeneration in a mouse AD model (Branca et al., 2017; Rojo et al., 2018), whereas activating Nrf2 (by knocking down its negative regulator) led to the reduction in oxidative stress and neuroinflammation (Williamson et al., 2012).