Removing Nrf2 increased the levels of Aβ and phosphorylated tau and enhanced neurodegeneration in a mouse AD model (Branca et al., 2017; Rojo et al., 2018), whereas activating Nrf2 (by knocking down its negative regulator) led to the reduction in oxidative stress and neuroinflammation (Williamson et al., 2012). This evidence concerns the gene NFE2L2 and Alzheimer disease.