Moreover, Kraemer and colleagues showed that inhibition of cell division cycle 7-related protein kinase (CDC7) by the small molecule inhibitor PHA767491 could reduce TDP-43 phosphorylation and prevent TDP-43-triggered neurodegeneration in C. elegans ALS models (Liachko et al., 2013). This evidence concerns the gene CDC7 and amyotrophic lateral sclerosis.