RUNX2 and ocular melanoma: The results demonstrated that the OM culture significantly increased the expression of CDK1, MKI67, and Runx2. However, after the addition of AGP to the OM culture, CDK1, MKI67, and Runx2 were significantly downregulated (* vs control group p < 0.05; # vs OM + DMSO group p < 0.05; Figure 4A).