To compare the performance of radiomics and deep learning in predicting EGFR mutation status in patients with NSCLC based on PET/CT images, three models were established based on PET/CT images in this study, namely, radiomics model (RM), deep learning model (DLM), and hybrid model (HM), and they were compared the performance in identifying EGFR mutation status. The gene discussed is EGFR; the disease is non-small cell lung carcinoma.