The role of CXCR2 in the bladder function and visceral hypersensitivity in CYP-induced cystitis and the antinociceptive effect of a selective antagonist of CXCR2, SB225002, have been recently reported in another CYP-induced IC rat model (Dornelles et al., 2014). This evidence concerns the gene CXCR2 and chronic cystitis.