CXCR2 and peripheral neuropathy: On the other hand, in our model of non-Hunner IC/BPS, DF2755A alone as preventive or therapeutic treatment was strikingly protective against CYP-induced peripheral neuropathy, thus demonstrating that CXCR2 plays also a crucial role in the pathophysiology of IC-related neuropathic pain that is independent from tissue inflammatory infiltrate.