PPIG and peripheral neuropathy: Interestingly, at 3 and 7 days after treatment discontinuation, DF2755A still exerted a strong and significant therapeutic effect against CYP-induced peripheral neuropathy at the level of both low abdomen, with 53 and 95% reduction of the threshold to mechanical stimulus in the DF2755A-treated group and vehicle-treated animals, respectively (Figure 4A), and hind paw plantar surfaces with 40 and 92% decrease of the threshold to mechanical stimulus in the DF2755A-treated group and vehicle-treated animals, respectively (Figure 4B).