To investigate the underlying mechanisms involved in DF2755A antinociceptive effects in CYP-induced peripheral neuropathy, we analyzed bladder tissue expression of the chemokines CXCL1/KC and CXCL5, which are CXCR2 agonists, and of transient receptor potential vanilloid 1 (TRPV1), a factor known to be crucial for pain modulation in IC/BPS pathophysiology (Z.Y. Wang ZY. Here, CALCA is linked to peripheral neuropathy.