In line with previous studies (Augé et al., 2020; 2021), repeated injections of CYP-induced peripheral neuropathy in female SD rats, dramatically decreasing the withdrawal thresholds to noxious stimuli measured 24 h after the last CYP administration at the level of low abdomen (Figure 1A) and hind paws (Figure 1B). Here, PPIG is linked to peripheral neuropathy.