For instance, in hepatocellular carcinoma, METTL3 is associated with a poor prognosis and inhibits the suppressor of cytokine signaling 2 (i.e., SOCS2) expression through the miR-145/m 6 A/YTHDF2-dependent axis (Yang et al., 2017; Chen et al., 2018). This evidence concerns the gene SOCS2 and hepatocellular carcinoma.