NR2F2-AS1 can down-regulate the expression of PDCD4 and inhibit the development of gastric cancer through competitive binding with miR-320b, it can also inhibit miR-494 methylation to regulate oral squamous cell carcinoma cells proliferation (Liang et al., 2022; Luo et al., 2022). This evidence concerns the gene NR2F2 and oral cavity squamous cell carcinoma.