CXCL16/CXCR6 axis acts a pivotal part in the pro-tumor microenvironment, and the silencing of CXCR6 reduced the proliferation rate on glioma cells (Lepore et al., 2018), indicating that CXCR6 plays an oncogenic role in glioma. This evidence concerns the gene CXCR6 and glioma.