CD274 and cutaneous melanoma: Similar to LUAD, skin cutaneous melanoma (SKCM) has a high ORR in first-line immunotherapy (Brahmer et al., 2015; Garon et al., 2015; Larkin et al., 2015), and a systematic review revealed that both PD-L1–negative and PD-L1–positive patients can benefit from the ICIs (Teng et al., 2018), implying the strong immunogenicity of SKCM.