The PSTPIP1 hub gene was related to T-cell activation, differentiation, and migration, modulating the function of innate immune cells and the innate immune response, and its mutation was confirmed as a crucial driver of immunodeficiency and auto-inflammatory diseases (Holzinger and Roth, 2016; Janssen et al., 2018). The gene discussed is PSTPIP1; the disease is Immunodeficiency.