The research recruited genomic data from 22,161 participants of European ancestry for analysis and found 29 common variants associated with MetS or MetS components, and the majority of them were located in genes participating in lipid metabolism (Kraja et al., 2011), the most influential of which included LPL, CETP, APOA5, ZNF259, BUD13, TRIB1, LOC100129500, and LOC100128154. Here, APOA5 is linked to metabolic syndrome.