For MetS intervention, increased physical activity (in particular aerobic exercise) has been shown to improve dyslipidemia and insulin sensitivity, and more specifically, resistance training plus aerobic high-intensity interval training improves fasting glucose low density lipoprotein and insulin secretion, while resistance training plus moderate-intensity continuous aerobic training reduces triglycerides (Da Silva et al., 2020). The gene discussed is INS; the disease is metabolic syndrome.