TCF7L2 and metabolic syndrome: Such as on the genomic level, GWAS has designated several variants affecting drug response for MetS components, including rs3846662 located on intron 13 of HMGCR for simvastatin, Rs776746 (C/T) variant found on CYP3A5 gene for a statin, and rs12255372 of TCF7L2 gene for sulfonylureas (Jmel et al., 2018).