TCF7L2 and metabolic syndrome: Several genetic factors have been studied to potentially contribute to this heterogeneity including SNPs for FTO, MC4R, PPARγ2, and ADRB3 for central obesity, APOA5, LIPC, CETP, FADS2, APOB, and PGS1 for dyslipidemia, P13K, LIPC, ADRA2B, TCF7L2, PPARγ2, and ENPP1 for hyperglycemia, and ACE for hypertension (Fenwick et al., 2019).