With respect to the TP53 IVS3 16 bp polymorphism, 6 studies (Dunning et al., 1999; Hu et al., 2010a; Hu et al., 2010b; He et al., 2011; Sagne et al., 2013; Wu et al., 2013; Diakite et al., 2020a) found an obviously increased BC risk in overall analysis. The gene discussed is TP53; the disease is breast cancer.