We reviewed the literature and found that AGAP2-AS1, HOTAIR, and HOXC-AS1 (three lncRNAs of GILncSig) are not only related to the malignant progression of tumors and poor prognosis of patients (Tan et al., 2018a; Tan et al., 2018b; Dong et al., 2019) but also affect the tumor immune microenvironment (Wang et al., 2018; Botti et al., 2019). Here, HOTAIR is linked to neoplasm.