The expression of PD-L1, CTLA4, TIM-3, and CD96 was significantly higher in high-risk populations than in low-risk populations, indicating that GILncSig expression was related to a high tumor immune resistance (Li et al., 2017b; Saha et al., 2017; Xue et al., 2017; Liu et al., 2020). The gene discussed is CD96; the disease is neoplasm.