Higher methylation levels at TNFRSF10C (tumor necrosis factor receptor superfamily member 10C) promoter region in peripheral blood and cancer tissue was positively associated with perineural tumor spread in pancreatic adenocarcinoma (Dauksa et al., 2012); however, it will be necessary to follow the gene expression regulation of this gene in HNSCC patients. This evidence concerns the gene TNFRSF10C and head and neck squamous cell carcinoma.