Higher methylation levels at TNFRSF10C (tumor necrosis factor receptor superfamily member 10C) promoter region in peripheral blood and cancer tissue was positively associated with perineural tumor spread in pancreatic adenocarcinoma (Dauksa et al., 2012); however, it will be necessary to follow the gene expression regulation of this gene in HNSCC patients. The gene discussed is TNFRSF10C; the disease is pancreatic adenocarcinoma.