In OMIM, four types of PCLD are included: PCLD1 (OMIM #174050) caused by heterozygous mutation in PRKCSH, PCLD2 (OMIM #617004) caused by heterozygous variant in SEC63, PCLD3 (OMIM #617874) caused by heterozygous mutant ALG8, and PCLD4 (OMIM#617875) caused by heterozygous mutation in LRP5. Among these four types, PCLD1 and PCLD2 are the most common types of PCLD. This evidence concerns the gene SEC63 and Isolated polycystic liver disease.